Bifurcation in Cell Cycle Dynamics Regulated by p53.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26090895.
- Also identified by DOI 10.1371/journal.pone.0129620 and PMC identifier 4474887.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases. The IR induced p53 dynamics undergo collapse of oscillation with collapse time Δt which depends on IR strength. The stress p53 via IR drive cell cycle molecular species MPF and cyclin dynamics to different states, namely, oscillation death, oscillations of periods, chaotic and sustain oscillation in their bifurcation diagram. We predict that there could be a critical Δtc induced by p53 via IRc, where, if Δt〈Δtc the cell cycle may come back to normal state, otherwise it will go to cell cycle arrest (apoptosis).
Medical subject headings
- Cell Cycle
- Tumor Suppressor Protein p53