ER Stress in Dendritic Cells Promotes Cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26091029.
- Also identified by DOI 10.1016/j.cell.2015.06.006.
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Abstract
XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy.
Medical subject headings
- DNA-Binding Proteins
- Dendritic Cells
- Endoplasmic Reticulum Stress
- Ovarian Neoplasms
- Transcription Factors