Wnt Down, Tumors Wind Up?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26091030.
- Also identified by DOI 10.1016/j.cell.2015.06.008.
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Abstract
In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an exquisite target for intervention.
Medical subject headings
- Adenomatous Polyposis Coli Protein
- Colorectal Neoplasms
- Disease Models, Animal
- Intestine, Large
- Intestine, Small