A Shortcut to Activity-Dependent Transcription.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26091031.
- Also identified by DOI 10.1016/j.cell.2015.06.009.
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Abstract
Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.
Medical subject headings
- DNA Breaks, Double-Stranded
- Neurons