Linking Micronuclei to Chromosome Fragmentation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26091034.
- Also identified by DOI 10.1016/j.cell.2015.06.005.
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Abstract
Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.
Medical subject headings
- Chromosome Breakage
- DNA Damage
- Micronuclei, Chromosome-Defective