Hydrogel Nanofilaments via Core-Shell Electrospinning.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26091487.
- Also identified by DOI 10.1371/journal.pone.0129816 and PMC identifier 4474634.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent biomedical hydrogels applications require the development of nanostructures with controlled diameter and adjustable mechanical properties. Here we present a technique for the production of flexible nanofilaments to be used as drug carriers or in microfluidics, with deformability and elasticity resembling those of long DNA chains. The fabrication method is based on the core-shell electrospinning technique with core solution polymerisation post electrospinning. Produced from the nanofibers highly deformable hydrogel nanofilaments are characterised by their Brownian motion and bending dynamics. The evaluated mechanical properties are compared with AFM nanoindentation tests.
Medical subject headings
- Hydrogels
- Nanostructures