ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.
Where this comes from
- Record sourced from PubMed, PMID 26107936.
- Also identified by DOI 10.1371/journal.pone.0131078 and PMC identifier 4481100.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
To investigate the genetic basis of erythromycin resistance in Riemerella anatipestifer, the MIC to erythromycin of 79 R. anatipestifer isolates from China and one typed strain, ATCC11845, were evaluated. The results showed that 43 of 80 (53.8%) of the tested R. anatipestifer strains showed resistance to erythromycin, and 30 of 43 erythromycin-resistant R. anatipestifer strains carried ermF or ermFU with an MIC in the range of 32-2048 μg/ml, while the other 13 strains carrying the ereD gene exhibited an MIC of 4-16 μg/ml. Of 30 ermF + R. anatipestifer strains, 27 (90.0%) carried the ermFU gene which may have been derived from the CTnDOT-like element, while three other strains carried ermF from transposon Tn4351. Moreover, sequence analysis revealed that ermF, ermFU, and ereD were located within the multiresistance region of the R. anatipestifer genome.
Medical subject headings
- Anti-Bacterial Agents
- Bacterial Proteins
- Drug Resistance, Bacterial
- Drug Resistance, Microbial
- Erythromycin
- Methyltransferases
- Riemerella