Developing predictive assays: the phenotypic screening "rule of 3".
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26109101.
- Also identified by DOI 10.1126/scitranslmed.aab1201.
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Abstract
Phenotypic drug discovery approaches can positively affect the translation of preclinical findings to patients. However, not all phenotypic assays are created equal. A critical question then follows: What are the characteristics of the optimal assays? We analyze this question and propose three specific criteria related to the disease relevance of the assay-system, stimulus, and end point-to help design the most predictive phenotypic assays.
Medical subject headings
- Biological Assay
- Drug Evaluation, Preclinical