Varicella Zoster Virus in Temporal Arteries of Patients With Giant Cell Arteritis.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 26116729.
- Also identified by DOI 10.1093/infdis/jiu542 and PMC identifier 4574553.
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Abstract
Giant cell arteritis (GCA) is an immune-mediated disease of unknown etiology. Varicella zoster virus (VZV) antigen was found in all of 4 GCA-positive temporal arteries (TAs) but was not present in any of 13 normal TAs. All 4 GCA-positive TAs contained viral antigen in skip areas, mostly in the adventitia and media and least in the intima. Despite formalin fixation, VZV DNA was detected in 2 of 4 GCA-positive, VZV antigen-positive TAs. Skeletal muscle was attached to 3 of 4 TAs, and VZV antigen was found in 2 and VZV DNA in 1. VZV may cause GCA.
Medical subject headings
- Giant Cell Arteritis
- Herpesvirus 3, Human
- Temporal Arteries