Fabrication of 3D Scaffolds with Precisely Controlled Substrate Modulus and Pore Size by Templated-Fused Deposition Modeling to Direct Osteogenic Differentiation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26121662.
- Also identified by DOI 10.1002/adhm.201500099 and PMC identifier 4558627.
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Abstract
Scaffolds with tunable mechanical and topological properties fabricated by templated-fused deposition modeling promote increased osteogenic differentiation of bone marrow stem cells with increasing substrate modulus and decreasing pore size. These findings guide the rational design of cell-responsive scaffolds that recapitulate the bone microenvironment for repair of bone damaged by trauma or disease.
Medical subject headings
- Cell Differentiation
- Osteogenesis
- Tissue Scaffolds