Pathway and network analysis of cancer genomes.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 26125594.
- Also identified by DOI 10.1038/nmeth.3440 and PMC identifier 4717906.
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Abstract
Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.
Medical subject headings
- Gene Regulatory Networks
- Genome
- Neoplasms
- Signal Transduction