The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26126088.
- Also identified by DOI 10.1038/ki.2015.87 and PMC identifier 4487414.
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Abstract
Normalization of acid-base homeostasis in chronic kidney disease (CKD) holds promise for mitigating disease progression, but whether efforts should focus on patients with low serum bicarbonate or high dietary acid load is unknown. Vallet et al. report that low urinary ammonia excretion independently associates with increased progression in moderate CKD. Whether this finding implicates differences in endogenous acid production or the ability to excrete an acid load in the pathogenesis of progression requires further study.
Medical subject headings
- Ammonia
- Carbon Dioxide
- Renal Insufficiency, Chronic