Association of the Functional MICA-129 Polymorphism With the Severity of Chronic Chagas Heart Disease.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 26129751.
- Also identified by DOI 10.1093/cid/civ540 and PMC identifier 4583584.
- Licence recorded as CC BY-NC-ND.
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Abstract
MICA-129 polymorphism affects the binding affinity of MICA molecules with the NKG2D receptor and influences effector cell function. The genotype met/met was associated with the severity of left ventricular systolic dysfunction (LVSD) in patients with chronic Chagas heart disease, while the val/val genotype was associated with the absence of LVSD.
Medical subject headings
- Chagas Cardiomyopathy
- Histocompatibility Antigens Class I
- NK Cell Lectin-Like Receptor Subfamily K
- Polymorphism, Genetic
- Ventricular Dysfunction, Left