A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26136472.
- Also identified by DOI 10.1093/infdis/jiv358 and PMC identifier 4676544.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Recent clinical trials revealed a surprisingly rapid clearance of red blood cells (RBCs) infected with malaria parasites by the spiroindolone KAE609. Here, we show that ring-stage parasite-infected RBCs exposed to KAE609 become spherical and rigid, probably through osmotic dysregulation consequent to the disruption of the parasite's sodium efflux pump (adenosine triphosphate 4). We also show that this peculiar drug effect is likely to cause accelerated splenic clearance of the rheologically impaired Plasmodium vivax- and Plasmodium falciparum-infected RBCs.
Medical subject headings
- Antimalarials
- Indoles
- Malaria, Falciparum
- Plasmodium falciparum
- Plasmodium vivax
- Spiro Compounds