Direct Reprogramming of RESTing Astrocytes.

Wang, Chengzhong; Fong, Helen; Huang, Yadong · Cell Stem Cell · 2015

editorial · Level V

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Abstract

Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determination and identify circuits that mediate cellular identity.

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