Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26147722.
- Also identified by DOI 10.1371/journal.pone.0132175 and PMC identifier 4492988.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.
Medical subject headings
- Coumarins
- Free Radical Scavengers
- Hydrogen Peroxide