Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 26147760.
- Also identified by DOI 10.1038/nm.3891.
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Abstract
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 °C) increased peripheral insulin sensitivity by ∼43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.
Medical subject headings
- Acclimatization
- Diabetes Mellitus, Type 2
- Insulin Resistance