Breaking the Barrier--Chaperone-Mediated Autophagy of Perilipins Regulates the Lipolytic Degradation of Fat.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26154053.
- Also identified by DOI 10.1016/j.cmet.2015.06.017.
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Abstract
Triglyceride hydrolysis by cytosolic and lysosomal lipases mobilizes fatty acids from lipid droplet stores. Kaushik and Cuervo (2015) found that chaperone-mediated autophagy removes the protective barrier from the lipid droplet surface, facilitating lipolysis by cytosolic lipases and assembly of autolipophagosomes for subsequent lysosomal lipid degradation.
Medical subject headings
- Autophagy
- Lipid Droplets
- Lipolysis
- Liver
- Molecular Chaperones