Dimensionality of Rolled-up Nanomembranes Controls Neural Stem Cell Migration Mechanism.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26161791.
- Also identified by DOI 10.1021/acs.nanolett.5b02099 and PMC identifier 4538455.
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Abstract
We employ glass microtube structures fabricated by rolled-up nanotechnology to infer the influence of scaffold dimensionality and cell confinement on neural stem cell (NSC) migration. Thereby, we observe a pronounced morphology change that marks a reversible mesenchymal to amoeboid migration mode transition. Space restrictions preset by the diameter of nanomembrane topography modify the cell shape toward characteristics found in living tissue. We demonstrate the importance of substrate dimensionality for the migration mode of NSCs and thereby define rolled-up nanomembranes as the ultimate tool for single-cell migration studies.
Medical subject headings
- Cell Movement
- Nanostructures
- Neural Stem Cells
- Tissue Scaffolds