Translating Pembrolizumab to Clinical Practice: Speak Immunology and Learn Fast!

van Elsas, Andrea; van Eenennaam, Hans; Haanen, John B · Clin Cancer Res · 2015

review · Level V

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Abstract

T-cell checkpoint inhibitors treat the cancer patient's immune system potentially inducing significant long-term survival. Pembrolizumab demonstrates clinical activity in patients diagnosed with melanoma and other cancers. Its mode of action suggests a rationale for combination with other treatment modalities, urging oncologists to brush up their knowledge of immunology.

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