Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26178920.
- Also identified by DOI 10.1002/adma.201501803 and PMC identifier 4699560.
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Abstract
An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.
Medical subject headings
- Antineoplastic Agents, Phytogenic
- Drug Carriers
- Fibrosarcoma
- Matrix Metalloproteinases
- Nanoparticles
- Paclitaxel