Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26185094.
- Also identified by DOI 10.1093/infdis/jiv240 and PMC identifier 4564549.
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Abstract
Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-α7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-α7 was not sufficient to increase survival rates among mice infected with EBOV.
Medical subject headings
- Ebolavirus
- Hemorrhagic Fever, Ebola
- Inclusion Bodies, Viral
- Virulence
- alpha Karyopherins