Optical Control of Microtubule Dynamics in Time and Space.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26186185.
- Also identified by DOI 10.1016/j.cell.2015.06.064.
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Abstract
Small molecule inhibitors of microtubule dynamics are widely used as cell biology research tools and clinically as cancer chemotherapeutics. By slight modification to the chemical structure of a known microtubule inhibitor, combretastatin A-4, Borowiak et al. develop a photoswitchable derivative that can be turned "on" and "off" with low-intensity light to spatially and temporally control microtubule dynamics.
Medical subject headings
- Antimitotic Agents
- Cell Death
- Microtubules
- Mitosis
- Stilbenes