SnapShot: Spliceosome Dynamics II.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26186196.
- Also identified by DOI 10.1016/j.cell.2015.06.061.
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Abstract
Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to regulate splicing. The majority of higher eukaryotic protein-coding genes contain more than one intron and the derived pre-mRNAs can be alternatively spliced. Diverse principles ensure the reliable identification of authentic splice sites while concomitantly providing flexibility in splice site choice during alternative splicing. Some species contain a second type of minor (U12-type) spliceosome.
Medical subject headings
- RNA Splicing
- Spliceosomes