Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26197973.
- Also identified by DOI 10.1002/adma.201501304 and PMC identifier 4858817.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Porous silicon nanoneedles can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma.
Medical subject headings
- Biosensing Techniques
- Cathepsin B
- Cytosol
- Esophagus
- Nanotechnology
- Silicon