A Peptide-Network Weaved Nanoplatform with Tumor Microenvironment Responsiveness and Deep Tissue Penetration Capability for Cancer Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26198072.
- Also identified by DOI 10.1002/adma.201501502.
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Abstract
Novel core-shell tumor-penetrating vesicles consisting of a nanovesicle core with tumor-penetrating ligands and enzymatically degradable polymeric peptides anchored covalently to the core to form a thin polymeric shell are evaluated as drug-delivery systems. This delivery platform demonstrates an enhanced therapeutic efficacy attributed to the synergistic contributions from matrix metalloproteinase (MMP)-responsive drug release as well as improved tumor accumulation and penetration in the tumor microenvironment.
Medical subject headings
- Cell-Penetrating Peptides
- Drug Carriers
- Nanomedicine
- Nanostructures
- Tumor Microenvironment