Science to Practice: The Changing Face of Local Tumor Therapies-Do We Have to Think Systemically When Treating Cancer Locally?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26203703.
- Also identified by DOI 10.1148/radiol.2015150451 and PMC identifier 4520212.
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Abstract
In this issue, Rozenblum et al ( 1 ) were able to demonstrate that radiofrequency (RF) ablation-induced liver regeneration promotes "off-target" tumorigenesis in a MDR2 knock-out mouse model of hepatocellular carcinoma (HCC) in the setting of chronic liver inflammation. In addition, the authors demonstrated that blocking liver regeneration with a c-met inhibitor might attenuate or eliminate potential tumorigenic effects. These results provide the rationale for combined therapeutic approaches of RF ablation followed by a systemic application of immunomodulatory drugs.
Medical subject headings
- Ablation Techniques
- Carcinogenesis
- Carcinoma, Hepatocellular
- Electrosurgery
- Hepatectomy
- Liver Neoplasms