The MI bundle: enabling network and structural biology in genome visualization tools.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 26209801.
- Also identified by DOI 10.1093/bioinformatics/btv431 and PMC identifier 4817051.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Prioritization of candidate genes emanating from large-scale screens requires integrated analyses at the genomics, molecular, network and structural biology levels. We have extended the Integrated Genome Browser (IGB) to facilitate these tasks. The graphical user interface greatly simplifies building disease networks and zooming in at atomic resolution to identify variations in molecular complexes that may affect molecular interactions in the context of genomic data. All results are summarized in genome tracks and can be visualized and analyzed at the transcript level. The MI Bundle is a plugin for the IGB. The plugin, help, video and tutorial are available at http://cru.genomics.iit.it/igbmibundle/ and https://github.com/CRUiit/igb-mi-bundle/wiki. The source code is released under the Apache License, Version 2. arnaud.ceol@iit.it Supplementary data are available at Bioinformatics online.
Medical subject headings
- Genome
- Genomics
- Software