Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26214046.
- Also identified by DOI 10.1021/acs.nanolett.5b02859.
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Abstract
Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels with unprecedented stiffness of up to 40 kPa. These biocompatible scaffolds support the three-dimensional culture of human stem cells and differentiation of primary cells into organotypic (gastrointestinal and skin) structures for high-throughput screening, diagnosis, and tissue engineering.
Medical subject headings
- Nanofibers
- Peptides
- Tissue Scaffolds