Paper diagnostic device for quantitative electrochemical detection of ricin at picomolar levels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26224395.
- Also identified by DOI 10.1039/c5lc00731c.
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Abstract
We report a paper-based assay platform for detection of ricin a chain. The paper platform is assembled by simple origami paper folding. The sensor is based on quantitative, electrochemical detection of silver nanoparticle labels linked to a magnetic microbead support via a ricin immunosandwich. Importantly, ricin was detected at concentrations as low as 34 pM. Additionally, the assay is robust, even in the presence of 100-fold excess hoax materials. Finally, the device is easily remediated after use by incineration. The cost of the device, not including reagents, is just $0.30. The total assay time, including formation of the immunosandwich, is 9.5 min.
Medical subject headings
- Electrochemical Techniques
- Metal Nanoparticles
- Paper
- Ricin
- Silver