Inflammation and hypoxia in the kidney: friends or foes?
Where this comes from
- Record sourced from PubMed, PMID 26230196.
- Also identified by DOI 10.1038/ki.2015.89 and PMC identifier 4534718.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hypoxic injury is commonly associated with inflammatory-cell infiltration, and inflammation frequently leads to the activation of cellular hypoxia response pathways. The molecular mechanisms underlying this cross-talk during kidney injury are incompletely understood. Yamaguchi and colleagues identify CCAAT/enhancer-binding protein δ as a cytokine- and hypoxia-regulated transcription factor that fine-tunes hypoxia-inducible factor-1 signaling in renal epithelial cells and thus provide a novel molecular link between hypoxia and inflammation in kidney injury.
Medical subject headings
- CCAAT-Enhancer-Binding Protein-delta
- Gene Expression Regulation
- Hypoxia
- Hypoxia-Inducible Factor 1, alpha Subunit
- Kidney
- Nephritis