Gluten and IgA nephropathy: you are what you eat?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26230197.
- Also identified by DOI 10.1038/ki.2015.149.
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Abstract
Although extensively studied, the relationship between dietary antigens-in particular, gluten-and IgA nephropathy remains unclear. Using a double transgenic mouse model of IgA nephropathy that expresses both human IgA1 and human CD89, Papista et al. report that a gluten-free diet protects against the development of IgA deposition and glomerular injury, and that these events occur with the introduction of dietary gluten.
Medical subject headings
- Antigens, CD
- Glomerulonephritis, IGA
- Glutens
- Immunoglobulin A
- Intestinal Mucosa
- Receptors, Fc