Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 26233928.
- Also identified by DOI 10.1016/j.jaci.2015.05.048 and PMC identifier 4562810.
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Abstract
Group 2 innate lymphoid cells (ILC2s) produce high levels of IL-5 and IL-13, both of which are important pathogenic mediators in eosinophilic esophagitis (EoE). ILC2s have not been previously described in EoE. Our study demonstrates the novel finding that ILC2s are increased in esophageal biopsies from EoE patients with active disease compared with inactive EoE and non-diseased controls, implicating these cells in EoE pathogenesis.
Medical subject headings
- Cytokines
- Eosinophilic Esophagitis
- Eosinophils
- Esophagus
- Interleukin-33
- Lymphocyte Subsets