Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26239035.
- Also identified by DOI 10.1002/adma.201502243.
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Abstract
Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.
Medical subject headings
- Blood Platelets
- Drug Carriers
- Oxazoles
- Platelet Activation
- Thrombin