The ART of Lowering Ceramides.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26244926.
- Also identified by DOI 10.1016/j.cmet.2015.07.019.
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Abstract
Ceramides are lipid metabolites implicated in the metabolic dysregulation that accompanies dyslipidaemia and obesity. Using a genetic mouse model to acutely degrade ceramides in adipose tissue or the liver (i.e., by conditionally expressing acid ceramidase), in this issue of Cell MetabolismXia et al. (2015) identify roles for these molecules in insulin resistance, steatohepatitis, and interorgan communication.
Medical subject headings
- Acid Ceramidase
- Ceramides
- Fatty Liver
- Liver