Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26244927.
- Also identified by DOI 10.1016/j.cmet.2015.07.014 and PMC identifier 4862576.
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Abstract
The molecular clock is a master controller of circadian cellular processes that affect growth, metabolic homeostasis, and behavior. A report in Science by Zhang et al. (2015) redefines our understanding of how Rev-erba acts as an internal feedback inhibitor that modulates activity of the core clock while simultaneously regulating tissue-specific metabolic processes.
Medical subject headings
- CLOCK Proteins
- Circadian Clocks
- Circadian Rhythm
- Gene Expression Regulation
- Histone Deacetylases
- Metabolism
- Nuclear Receptor Subfamily 1, Group D, Member 1