A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia.
basic_science · Level V
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- Record sourced from PubMed, PMID 26244928.
- Also identified by DOI 10.1016/j.cmet.2015.07.016.
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Abstract
Two articles in this issue (Intlekofer et al., 2015; Oldham et al., 2015) show a new metabolic pathway regulated by hypoxia, but independently of HIF1 or HIF2. L-2-hydroxyglutarate, produced in hypoxia by malate dehydrogenases and LDHA, is a potent inhibitor of KDM4C, and through redox stress reduces glycolysis.