NNMT: A Bad Actor in Fat Makes Good in Liver.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26244929.
- Also identified by DOI 10.1016/j.cmet.2015.07.017 and PMC identifier 4768475.
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Abstract
High adipose expression of NNMT, an enzyme that converts nicotinamide to 1-methyl-nicotinamide, correlates with adiposity. Though murine NNMT knockdown in fat and liver prevents weight gain on high-fat diet, Hong et al. (2015) now show that high hepatic expression of NNMT improves lipid parameters via SIRT1 stabilization.
Medical subject headings
- Liver
- Nicotinamide N-Methyltransferase
- Sirtuin 1