Supporting itch: a new role for astrocytes in chronic itch.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26248264.
- Also identified by DOI 10.1038/nm.3921 and PMC identifier 6053542.
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Abstract
A new study shows that astrocytes are involved in the development of chronic itch in a mouse model. This dependent on upregulation of lipocalin 2 (LCN2) by the transcription factor STAT-3 and astrogliosis.
Medical subject headings
- Pruritus
- STAT3 Transcription Factor
- Spinal Cord Dorsal Horn