Small Molecules Take a Big Step by Converting Fibroblasts into Neurons.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26253195.
- Also identified by DOI 10.1016/j.stem.2015.07.018.
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Abstract
Direct lineage conversion could provide a rich source of somatic cell types for translational medicine, but concerns over the use of transgenic reprogramming factors have limited its potential. In this issue of Cell Stem Cell, Li et al. (2015) and Hu et al. (2015) identify small-molecule cocktails that can convert fibroblasts into functional neurons without exogenous genetic factors.
Medical subject headings
- Alzheimer Disease
- Cellular Reprogramming
- Fibroblasts
- Neurons
- Small Molecule Libraries