Resistance in the Ribosome: RUNX1, pre-LSCs, and HSPCs.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 26253196.
- Also identified by DOI 10.1016/j.stem.2015.07.012 and PMC identifier 4541802.
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Abstract
Therapeutic targeting of pre-leukemic stem cells (pre-LSCs) may be a viable strategy to eradicate residual disease and prevent leukemia relapse. Now in Cell Stem Cell, Cai et al. (2015) show that loss-of-function mutations in RUNX1 reduce ribosome biogenesis and provide pre-LSCs a selective advantage over normal hematopoietic cells through increased stress resistance.
Medical subject headings
- Core Binding Factor Alpha 2 Subunit
- Hematopoietic Stem Cells
- Organelle Biogenesis
- Ribosomes