Artificial Loading of ASC Specks with Cytosolic Antigens.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26258904.
- Also identified by DOI 10.1371/journal.pone.0134912 and PMC identifier 4530869.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Inflammasome complexes form upon interaction of Nod Like Receptor (NLR) proteins with pathogen associated molecular patterns (PAPMS) inside the cytosol. Stimulation of a subset of inflammasome receptors including NLRP3, NLRC4 and AIM2 triggers formation of the micrometer-sized spherical supramolecular complex called the ASC speck. The ASC speck is thought to be the platform of inflammasome activity, but the reason why a supramolecular complex is preferred against oligomeric platforms remains elusive. We observed that a set of cytosolic proteins, including the model antigen ovalbumin, tend to co-aggregate on the ASC speck. We suggest that co-aggregation of antigenic proteins on the ASC speck during intracellular infection might be instrumental in antigen presentation.
Medical subject headings
- Antigen Presentation
- CARD Signaling Adaptor Proteins
- Calcium-Binding Proteins
- Carrier Proteins
- DNA-Binding Proteins
- Inflammasomes