The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly.

van Werkhoven, Cornelis H; Huijts, Susanne M; Bolkenbaas, Marieke; Grobbee, Diederick E; Bonten, Marc J M · Clin Infect Dis · 2015

rct · Level II

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Abstract

In a post hoc analysis of the Community-Acquired Pneumonia (CAP) immunization Trial in Adults the model-predicted 13-valent pneumococcal conjugate vaccine efficacy for preventing vaccine-type specific CAP and Invasive Pneumococcal Disease declined from 65% to 40% for subjects being 65 and 75 year olds at the time of vaccination, respectively.

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