Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26270904.
- Also identified by DOI 10.1002/adma.201502227.
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Abstract
As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress.
Medical subject headings
- Alzheimer Disease
- Contrast Media
- Drug Carriers
- Magnetite Nanoparticles
- Theranostic Nanomedicine