Revealing the trehalose mediated inhibition of protein aggregation through lysozyme-silver nanoparticle interaction.
basic_science · Level V
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- Record sourced from PubMed, PMID 26271458.
- Also identified by DOI 10.1039/c5sm01896j.
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Abstract
We propose a facile and robust carbohydrate-mediated method for the prevention of nanoparticle induced denaturation and aggregation of proteins. Using label-free plasmon-enhanced Raman spectroscopy measurements, the mechanistic principles of trehalose stabilization in a model protein-nanoparticle system are elucidated for the first time, facilitating its further application in diagnostic and therapeutic nanoplex development.
Medical subject headings
- Metal Nanoparticles
- Muramidase
- Protein Aggregates
- Trehalose