Simultaneous occurrence of focal nodular hyperplasia and HNF1A-inactivated hepatocellular adenoma: a collision tumor simulating a composite FNH-HCA.
case_report · Level V
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- Record sourced from PubMed, PMID 26274031.
- Also identified by DOI 10.1097/PAS.0000000000000477.
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Abstract
Mixed focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) within a single tumor mass is rarely reported, and most of these cases are examples of tumors with features intermediate between FNH and HCA. Although a few reported cases are probably examples of true mixed tumors, none was evaluated immunohistochemically or confirmed by molecular analysis. We report a mixed FNH and HCA arising in a woman with several HNF1A-inactivated adenomas. Our case is the first case of mixed FNH and HNF1A-inactivated HCA documented by immunohistochemistry.
Medical subject headings
- Adenoma, Liver Cell
- Biomarkers, Tumor
- Focal Nodular Hyperplasia
- Gene Silencing
- Hepatocyte Nuclear Factor 1-alpha
- Liver Neoplasms
- Neoplasms, Complex and Mixed