Installing multifunctionality on titanium with RGD-decorated polyurethane-polyurea roxithromycin loaded nanoparticles: toward new osseointegrative therapies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26274361.
- Also identified by DOI 10.1002/adhm.201500245.
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Abstract
A novel class of polyurethane-polyurea nanoparticles (PUUa NPs) to install multifunctionality on biomaterials is presented. Biofunctionalization of titanium with roxithromycin loaded RGD-decorated PUUa NPs results in an outstanding improvement of osteoblast adhesion and strong suppression of bacterial attachment. This strategy represents a powerful approach to enhance the osseointegration of implant materials.
Medical subject headings
- Anti-Bacterial Agents
- Drug Carriers
- Nanoparticles
- Oligopeptides
- Roxithromycin