Cytoprotective Effects of Lysophospholipids from Sea Cucumber Holothuria atra.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26275144.
- Also identified by DOI 10.1371/journal.pone.0135701 and PMC identifier 4537208.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Lysophospholipids are important signaling molecules in animals and metazoan cells. They are widely distributed among marine invertebrates, where their physiological roles are unknown. Sea cucumbers produce unique lysophospholipids. In this study, two lysophospholipids were detected in Holothuria atra for the first time, lyso-platelet activating factor and lysophosphatidylcholine, with nuclear magnetic resonance and liquid chromatography-time-of-flight mass spectrometric analyses. The lipid fraction of H. atra contained lyso-platelet activating factor and lysophosphatidylcholine, and inhibited H2O2-induced apoptosis in the macrophage cell line J774A.1. The antioxidant activity of the lysophospholipid-containing lipid fraction of H. atra was confirmed with the oxygen radical absorbance capacity method. Our results suggest that the lysophospholipids from H. atra are potential therapeutic agents for the inflammation induced by oxidative stress.
Medical subject headings
- Apoptosis
- Cytoprotection
- Holothuria
- Lysophospholipids
- Macrophages
- Oxidative Stress