An AAA+ ATPase Clamshell Targets Transposition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26276624.
- Also identified by DOI 10.1016/j.cell.2015.07.050 and PMC identifier 5550827.
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Abstract
DNA transposition plays key roles in genome diversity, pathogenesis, and evolution. Yet, structural and mechanistic information on transposition targeting and regulation is limited. Arias-Palomo and Berger now define the decameric organization of the AAA+ ATPase IstB, unveiling key insights into its targeting and regulation of IstA transposase activity.
Medical subject headings
- Bacteria
- DNA Transposable Elements