A CTCF Code for 3D Genome Architecture.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 26276625.
- Also identified by DOI 10.1016/j.cell.2015.07.053 and PMC identifier 4745123.
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Abstract
The architectural protein CTCF plays a complex role in decoding the functional output of the genome. Guo et al. now show that the orientation of a CTCF site restricts its choice of interacting partner, thus creating a code that predicts the three-dimensional organization of the genome. We propose a DNA extrusion model to account for orientation-specific loop formation.
Medical subject headings
- Chromosomes
- Genetic Techniques
- Repressor Proteins